BDBM368426 US10227342, Example 58

SMILES CNCCN(C)c1cc(OC)c(Nc2ncc(C(=O)OC(C)C)c(n2)-c2cn(C)c3ccccc23)cc1NC(=O)C=C

InChI Key InChIKey=MRBXRYTXQWBQSS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 368426   

TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM368426(US10227342, Example 58)
Affinity DataIC50: <100nMAssay Description:A compound's ability in selectively inhibiting EGFR L858R and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine pro-B cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent